The altar, the central element in a Catholic church and the focal point of liturgical events, is built of Carrara onyx and inlaid with glass mosaic. It stands on a chancel (marble floor) designed to highlight and heighten its centrality and significance. The placement of the altar at the crossing marks its identity as the center and heart of the Cathedral. The centrality of the altar is further defined by four large chandeliers that hang in its vicinity. These, along with the other chandeliers and light fixtures, were designed by Roger Morgan, of New York, and installed in 1993. The altar contains relics of St. Gratus, Bishop of Aosta in Piedmont, Northern Italy, who died in 457, and St. Fenusta, an early Roman martyr buried in the Roman catacombs. The relics signify the call to sainthood of all who approach Christ's table and the link across space and time between every eucharist. The altar is visually related to the baptismal font, both in materials and style, symbolizing the close relationship between baptism and the Mass.

